That’s what a recent study conducted at the Duke Eye Center suggests. The study of more than 200 people, published on March 11 in the journal Ophthalmology Retina, proposes that a quick, noninvasive eye exam might one day allow eye doctors to check up on both your vision prescription and your brain health.
Healthy vs. Alzheimer’s-Affected Brains
The study looked at the eyes of individuals with healthy brains, 133 in the control group, and 39 people who are affected by Alzheimer’s disease. In the people with healthy brains, they found that microscopic blood vessels form a dense web at the back of the eye inside the retina. Alternatively, in those affected by Alzheimer’s disease, that web was less dense and even sparse in places. The differences in density were statistically significant after researchers controlled for factors including age, sex, and level of education, Duke ophthalmologist and retinal surgeon Sharon Fekrat, M.D., reported, the study’s senior author.
“We’re measuring blood vessels that can’t be seen during a regular eye exam and we’re doing that with relatively new noninvasive technology that takes high-resolution images of very small blood vessels within the retina in just a few minutes,” she said. “It’s possible that these changes in blood vessel density in the retina could mirror what’s going on in the tiny blood vessels in the brain, perhaps before we are able to detect any changes in cognition.”
The study found differences in the retinas of those with Alzheimer’s disease when compared to healthy people and to those with mild cognitive impairment, often a precursor to Alzheimer’s disease.
With nearly six million Americans living with Alzheimer’s disease, and no viable treatments or noninvasive tools for early diagnosis, its burden on families and the economy is heavy. Scientists at Duke Eye Center and beyond have studied other changes in the retina that could signal trouble upstream in the brain, such as thinning of some of the retinal nerve layers.
“We know that there are changes that occur in the brain in the small blood vessels in people with Alzheimer’s disease, and because the retina is an extension of the brain, we wanted to investigate whether these changes could be detected in the retina using a new technology that is less invasive and easy to obtain,” said Dilraj S. Grewal, M.D., a Duke ophthalmologist and retinal surgeon and a lead author on the study.
The Duke study used a noninvasive technology called optical coherence tomography angiography (OCTA). OCTA machines use light waves that reveal blood flow in every layer of the retina.
An OCTA scan could even reveal changes in tiny capillaries — most less than half the width of a human hair — before blood vessel changes show up on a brain scan such as an MRI or cerebral angiogram, which highlight only larger blood vessels. Such techniques to study the brain are invasive and costly.
“Ultimately, the goal would be to use this technology to detect Alzheimer’s early, before symptoms of memory loss are evident, and be able to monitor these changes over time in participants of clinical trials studying new Alzheimer’s treatments,” Fekrat said.
To read more about Alzheimer’s Disease and a possible vaccine, read our blog “Texas Research: Alzheimer’s Disease Vaccine in the Works.”
Materials provided by Duke University Medical Center.